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Toxic polyketides produced by Fusarium sp., an endophytic fungus isolated from Melia azedarach |
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| Authors: | Yang Sheng-Xiang Gao Jin-Ming Zhang Qiang Laatsch Hartmut |
| Institution: | a Research Centre for Natural Medicinal Chemistry, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China b Department of Organic Chemistry, University of Goettingen, Tammannstrasse 2, D-37077 Goettingen, Germany c Department of Chemical Engineering, Huainan Union University, Huainan 232038, Anhui, China |
| Abstract: | A new isocoumarin derivative named fusariumin (1), together with two known related resorcylic acid lactones aigialomycin D (2) and pochonin N (3), has been isolated from the cultures of Fusarium sp. LN-10, an endophytic fungus originated from the leaves of Melia azedarach. Their structures were established on the basis of extensive spectroscopic analyzes including 1D- and 2D- NMR (1H-1H COSY, HSQC, HMBC, and NOESY) experiments. Compounds 1-3 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina). |
| Keywords: | Melia azedarach Endophytic fungus Fusarium sp Isocoumarins Resorcylic acid lactones |
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