Dual function inhibitors of relevance to chronic obstructive pulmonary disease |
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Authors: | Dou Dengfeng He Guijia Alliston Kevin R Groutas William C |
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Institution: | Department of Chemistry, Wichita State University, Wichita, KS 67260, USA |
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Abstract: | The general strategy and rationale underlying the design of COPD therapeutics that possess protease inhibitory activity and are also capable of releasing a species that attenuates inflammation by inhibiting caspase-1, are described. The synthesis and in vitro biochemical evaluation of a dual function molecule that sequentially inhibits HNE and caspase-1 in a time-dependent manner is reported. |
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Keywords: | Elastase Caspase-1 ICE Inhibitor Dual function |
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