Anti-oxidant supplementation decreases TBA reactants in serum of elderly |
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Authors: | Matti Tolonen Seppo Sarna Markku Halme Seppo E J Tuominen Tuomas Westermarck Ulla-Riitta Nordberg Mirja Keinonen Jaap Schrijver |
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Institution: | (1) Department of Public Health, University of Helsinki, Haartmaninkatu 3, SF-00290 Helsinki, Finland;(2) Hartola Health Center, SF-19600 Hartola, Finland;(3) Lahti Health Center, SF-15100 Lahti, Finland;(4) Helsinki Central Institute for Mentally Retarded, SF-02400 Kirkkonummi, Finland;(5) Department of Applied Psychology, University of Helsinki, Fabianinkatu 28, SF-00100 Helsinki, Finand;(6) CIVO-TNO Institute, Postbus, 360, NL-3700 AJ Zeist, The Netherlands |
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Abstract: | An “anti-oxidant cocktail” consisting of betacarotene, vitamins B6, C, E, zinc, and selenium or corresponding placebos were given for one y as daily dietary supplements to 45 elderly residents
of a nursing home. Initially, the serum TBA reactant levels were higher (2.7±0.7 μmol/L) than those of an ad hoc control group
of healthy younger adults (2.3±0.6 μmol/L),p<0.01. After three mo supplementation, the levels among the verum elderly had decreased to 2.2±0.6 μmol/L, and they remained
at this lower level until the end of the study period, whereas the placebo group showed no change.
A significant inverse correlation (r=−0.428,p<0.01) existed between the concentrations of serum TBA reactants and whole blood selenium (B-Se), but only B-Se levels above
200 μg/L were associated with a decrease in serum lipid peroxides. Serum alpha-tocopherol concentration also correlated inversely
with serum TBA reactants but this correlation (r=−0.273,p<0.76) was not as strong as that of B-Se.
Deficient vitamin B6 status, in biochemical terms, was observed in 25% of the elderly; a daily supplement of 2 mg B6 fully cured all cases of deficiency. The verum group improved slightly in several psychological tests, whereas subjects on
placebo remained unchanged or deteriorated during the follow-up period. Clinical amelioration among the verum subjects was
reported by the nurses; no toxic side effects were reported. In conclusion, the elderly benefited biochemically and clinically
of dietary antioxidant supplements. |
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Keywords: | TBA reactants selenium whole blood serum lipid and inverse correlation |
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