Marked inhibition of gastric secretion by two prostaglandin analogs given orally to man

Two prostaglandin analogs, 15(S)-15-methyl PGE₂, methyl ester, and 16, 16-dimethyl PGE₂ were administered to human volunteers for their possible effect in inhibiting gastric secretion. Both analogs, given orally, inhibited gastric secretion stimulated by pentagastrin, and the effect was dose dependent. The inhibition lasted for more than 4 hours, and no side-effects were noted at the doses used. When given intraduodenally, through a thin tube swallowed the night before, 15($\text{S}$)-15-methyl PGE₂, methyl ester was more active than 16, 16-dimethyl PGE₂. In view of their oral and prolonged activity, these analogs may have clinical potential in the treatment of peptic ulcer.