PPARalpha and PPARgamma regulation of liver and adipose proteins in obese and dyslipidemic rodents |
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Authors: | Lanne Boel Dahllöf Björn Lindahl Charlotta Ebefors Kerstin Kanmert Ida von Bahr Helena Miliotis Tasso Nyström Ann-Christin Arnerup Gunnel Paulsons Ivar Kerb Santy Oakes Nick |
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Affiliation: | AstraZeneca R&D M?lndal, S-431 83 M?lndal, Sweden. boel.s.lanne@astrazeneca.com |
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Abstract: | Zucker fatty rats and ob/ob mice are both frequently used hyperlipidemic and insulin-resistant spontaneous genetic models of obesity. We used them to study the effect of PPAR agonists on the protein-expression level in liver and white adipose tissue. PPARalpha-agonist treatments of the rats resulted in that 27% of the quantified hepatic proteins were altered; implicating pronounced peroxisome proliferation and increase in capacity for beta-oxidation of fatty acids although no correction of plasma triglycerides were obtained. On treatment with PPARgamma agonists, adipose proteins were regulated to a much larger extent in the rats compared to mice, 18% and 2%, respectively. |
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