Inhibitory effect of interferons and tumor necrosis factor on syncytium formation by bovine leukemia virus |
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| Authors: | J Imanishi H Ike A Yamada |
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| Institution: | Département de Microbiologie, Université Médicale de la Préfecture de Kyoto, Japan. |
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| Abstract: | The treatments of the bovine spleen cells BESp with recombinant human leukocyte interferon (HuIFN-alpha A) and human fibroblast interferon (HuIFN-beta) inhibit the syncytium formation by bovine leukemia virus (BLV) and the virus yield, depending on the IFN doses. But HuIFN-gamma did not inhibit the syncytium formation. The tumor-necrosis factor (TNF) also inhibits the syncytium formation and the virus yield, depending on the TNF doses. Furthermore, the combination of the HuIFN-alpha A with the TNF inhibits the syncytium formation more strongly than the HuIFN-alpha A alone or the TNF alone. |
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