Effects of a new pyrazolo [3, 4-d]pyrimidine on growth and morphology of Candida albicans |
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| Authors: | A Califano Tiziana Poli G L Vannini |
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| Institution: | (1) Department of Dermatology, University of Ferrara, I-44100 Ferrara, Italy;(2) Institute of Pharmaceutical Chemistry, University of Ferrara, I-44100 Ferrara, Italy;(3) Institute of Botany, University of Ferrara, I-44100 Ferrara, Italy |
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| Abstract: | A new pyrazolo 3, 4-d]pyrimidine derivative was synthesized and its antifungal activity evaluated in vitro against mycelial and yeast cells of Candida albicans. The most striking ultrastructural changes following treatment with 10–30  g/ml (mycelia) and 25–75 g/ml (yeasts) consisted in the deterioration of the organelle membranes and in aberrant thickenings of the cell wall. The complete disorganization of the cytoplasmic structures seemed to be the final event. |
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