Local and average gloss from flat-faced sodium chloride tablets |
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| Authors: | Mikko Juuti Bert van Veen Kai-Erik Peiponen Jarkko Ketolainen Valtteri Kalima Raimo Silvennoinen Tuula T Pakkanen |
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| Institution: | (1) Department of Physics, University of Joensuu, PO Box 111, FI-80101 Joensuu, Finland;(2) Orion Pharma R&D, Orion Corporation, PO Box 425, FI-20101 Turku, Finland;(3) Department of Pharmaceutics, University of Kuopio, PO Box 1627, FI-70211 Kuopio, Finland;(4) Department of Chemistry, University of Joensuu, PO Box 111, FI-80101 Joensuu, Finland |
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| Abstract: | The purpose of this study was to detect local gloss and surface structure changes of sodium chloride tablets. The changes
in surface structure were reflected by gloss variation, which was measured using a diffractive optical element-based gloss-meter
(DOG). By scanning a surface area, we constructed a 2-dimensional gloss map that characterized the tablet’s surface structure.
The gloss variation results were compared with scanning electron microscopy (SEM) images and average surface roughness values
that were measured by conventional diamond stylus profilometry. The profilometry data showed a decrease in tablet surface
roughness as a function of compression force. In general, a smoother surface contributes to higher average gloss values. The
average gloss values for this material, in contrast, showed a decrease as a function of the compression force. The sequence
of particle fragmentation and deformation together with crack formation in sodium chloride particles resulted in a loss of
gloss for single sodium chloride particles at the tablet surfaces, which could be detected by the DOG. These results were
supported by the SEM images. The results show that detailed information regarding tablets’ surface structure changes can be
obtained by detection of local gloss variation and average gloss.
Published: January 13, 2006 |
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| Keywords: | gloss tablet surface structure sodium chloride |
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