A non-tree-based comprehensive study of metazoan Hox and ParaHox genes prompts new insights into their origin and evolution |
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| Authors: | Morgane Thomas-Chollier Valérie Ledent Luc Leyns Michel Vervoort |
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| Affiliation: | 1.Laboratoire de Bioinformatique des Génomes et des Réseaux (BiGRe),Université Libre de Bruxelles,Bruxelles,Belgium;2.Laboratory for Cell Genetics,Vrije Universiteit Brussel,Brussels,Belgium;3.Belgian EMBnet Node,Université Libre de Bruxelles,Brussels,Belgium;4.Development and Neurobiology Program,Institut Jacques Monod, UMR 7592 CNRS/Université Paris Diderot,Paris,France;5.UFR des Sciences du Vivant,Université Paris Diderot,Paris,France;6.Department of Computational Molecular Biology,Max Planck Institute for Molecular Genetics,Berlin,Germany |
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| Abstract: | Background Hox and the closely-related ParaHox genes, which emerged prior to the divergence between cnidarians and bilaterians, are the most well-known members of the ancient genetic toolkit that controls embryonic development across all metazoans. Fundamental questions relative to their origin and evolutionary relationships remain however unresolved. We investigate here the evolution of metazoan Hox and ParaHox genes using the HoxPred program that allows the identification of Hox genes without the need of phylogenetic tree reconstructions. |
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