Mammalian plasma proteins bindings with single-stranded DNA; their effect on DNA polymerization and degradation reactions

A number of physicochemical properties of blood plasma proteins of mice and piglets which display their primary affinity to single-stranded DNA are studied. These proteins exert an activating effect on DNA-polymerase alpha from the Ehrlich ascites carcinoma and an inhibitory effect on the venom phosphodiesterase. A comparison of properties of the proteins under study with those of antibodies to the single-stranded DNA described in the literature permits supposing an identity of these proteins.