A simple and efficient enzymatic procedure for the deprotection of two base labile chlorinated purine ribosides |
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Authors: | Diana I Roncaglia Alejandro M Schmidt Luis E Iglesias Adolfo M Iribarren |
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Institution: | (1) Centro de Estudios e Investigaciones, Universidad Nacional de Quilmes, Roque Sáenz Peña 180-(1876) Bernal, Provincia de Buenos Aires, Argentina |
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Abstract: | Base-labile 6-chloro-2,3,5-tri-O-acetylpurine riboside (1c) and 2-amino-6-chloro-2,3,5-tri-O-acetylpurine riboside (1d) were fully deacetylated through Candida antarctica B lipase hydrolysis, affording respectively 6-chloropurine riboside (2c) and 2-amino-6-chloro-purine riboside (2d). Quantitative results were found at pH 7 and 60 °C in 24 h for 1c and 72 h for 1d. This mild and simple enzymatic technique represents a convenient procedure for the removal of acetyl groups from such base labile halogenated nucleosides. |
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Keywords: | 2-amino-6-chloropurine riboside 6-chloropurine riboside deacetylation lipases nucleosides |
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