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Unidentified Antioxidant Defences of Human Plasma in Immobilized Patients: A Possible Relation to Basic Metabolic Rate |
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| Authors: | R Aejmelaeus T Mets -Ketel T Pirttil A Hervonen H Alho |
| Institution: | a Laboratory of Neurobiology, Medical School, University of Tampere, PO Box 607, Tampere, Finland b Department of Pharmacological Sciences, Medical School, University of Tampere, PO Box 607, Tampere, Finland c Department of Neurology, Tampere University Hospital, P.O. Box 2000, Tampere, Finland d Department of Gerontology, School of Public Health, University of Tampere. PO Box 607, Tampere, Finland e Department of Alcohol Research, National Public Health Institute, POB 719, Helsinki, Finland |
| Abstract: | Plasma total peroxyl radical scavenging capacity was studied in terminal patients who were chronically immobilized because of an acute (stroke) or chronic neurodegenerative disease (Alzheimer's disease). A luminometric assay was used to measure total antioxi-dant capacity (TRAP). The immobilized patients showed significant decrease in TRAP primarily because of a decrease in the concentration of unknown antioxidants. Our results suggest that human plasma may contain unknown antioxidants, the regulation of which could be related to the basic metabolic rate. |
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