Polymorphism of the Glutathione S-Transferase Genes (GSTT1, GSTM1) in West Siberian Patients with Atopic Bronchial Asthma |
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| Authors: | Freidin M B Bragina E Yu Ogorodova L M Puzyrev V P |
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| Institution: | (1) Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk, 634050, Russia;(2) Siberian State Medical University, Tomsk, 634050, Russia |
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| Abstract: | Polymorphism for the GSTT1 and GSTM1 null alleles was analyzed in 69 patients with atopic bronchial asthma (BA) and in 57 healthy individuals from Tomsk. The two samples did not differ in frequencies of genotypes 0/0 and + of either gene or in frequencies of genotype combinations. No association was observed for GST and BA severity. Thus, the GST null alleles proved to be unimportant for BA. |
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| Keywords: | atopic bronchial asthma glutathione S-transferase genes null allele polymorphism |
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