Cerebrospinal fluid from morphine-dependent rats precipitates opiate abstinence syndrome |
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| Authors: | D H Malin L Harter P D Jenkins R D Monfort P D Bruce P A Farley R Ferebee K L Thrasher D S Marullo |
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| Affiliation: | 1. Department of Pharmacology & Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran;2. Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran;3. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;1. Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, United States;2. Department of Psychology, University of Michigan, Ann Arbor, MI 48109, United States;1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, College of Medicine, University of South Florida, Tampa, FL;2. Birth Defects Surveillance Program, Department of Community and Family Health, College of Public Health, University of South Florida, Tampa, FL;3. Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX;1. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Physiology, Behbahan Faculty of Medical Sciences, Behbahan, Iran;3. Department of Physiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran;4. Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran;5. Department of Basic Sciences, Iranian Academy of Medical Sciences, Tehran, Iran;1. Laboratory of Neuroscience and Behavior, Department of Physiological Sciences, University of Brasilia, Brasília, Brazil;2. Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Neuroscience Research Center, Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran;5. Laboratory of Neuroscience and Behavior, University CEUMA, São Luís, Maranhão, Brazil;1. Applied Sports Technology, Exercise Medicine Research Centre (A-STEM), Swansea University, United Kingdom;2. School of Social and Health Sciences, Leeds Trinity University, United Kingdom;3. Welsh Rugby Union, Vale of Glamorgan, United Kingdom;4. Faculty of Life Sciences and Education, University of South Wales, United Kingdom;5. Welsh Institute of Performance Science, College of Engineering, Swansea University, United Kingdom |
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| Abstract: | Cerebrospinal fluid (CSF) was withdrawn from opiate-dependent rats following six hours of abstinence. It was infused into the third ventricle of opiate-dependent rats, precipitating immediate abstinence signs. The effect was similar to that of infusing the opiate antagonist naloxone, suggesting that opiate-dependent organisms may secrete an endogenous opiate antagonist substance. CSF withdrawn from non-dependent rats failed to precipitate an abstinence syndrome in morphine-dependent recipients. Conversely, CSF withdrawn from opiate-dependent rats following six hours of abstinence failed to precipitate an abstinence syndrome in non-dependent recipients. The active factor in the CSF is probably a peptide since it is filterable through a 10,000 MW filter and its activity is destroyed by three different proteolytic enzymes. |
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