Purpurinimides as photosensitizers: effect of the presence and position of the substituents in the in vivo photodynamic efficacy |
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| Authors: | Rungta A Zheng G Missert J R Potter W R Dougherty T J Pandey R K |
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| Affiliation: | Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. |
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| Abstract: | This study presents a novel approach for the regioselective synthesis of a series of alkyl ether analogues of purpurin-18-N-alkylimide. In the purpurinimide series, this is the first example which demonstrates that the presence and position of the substituents in the macrocycle makes a remarkable difference in the in vivo PDT efficacy. |
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