Proteinase-activated receptor 1 (PAR-1) and cell apoptosis |
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Authors: | A N Flynn A G Buret |
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Institution: | Department of Biological Sciences and Mucosal Inflammation Research Group, The University of Calgary, Calgary, Alberta T2N 1N4, Canada. |
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Abstract: | This review summarizes the main aspects and newest findings of how proteinase-activated receptor 1 (PAR-1) may modulate programmed cell death. Activation of PAR-1 has been found to induce or inhibit apoptosis in a variety of cells, depending on the dosage of its physiological agonist thrombin, or that of synthetic receptor activators. To date, cellular targets for PAR-1-mediated effects on apoptosis include neuronal, endothelial, and epithelial cells, fibroblasts, and tumor cells. The signaling pathways involved in the induction or prevention of apoptosis by PAR-1 activation are diverse, and include JAK/STAT, RhoA, myosin light chain kinase, ERK1/2, and various Bcl-2 family members. In view of the well-established involvement of microbial proteinases in host tissue malfunction, the article also elaborates on the possible significance of PAR-1 activation for the pathogenesis of infectious disease. |
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Keywords: | apoptosis epithelial cells microbial proteinases myosin light chain proteinase-activated recepter 1 |
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