Thirty-three years later, a glimpse at the ribonuclease III active site |
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Authors: | Zamore P D |
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Institution: | Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester 01655, USA. |
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Abstract: | RNase III endonucleases cleave double-stranded RNA, transforming precursor RNAs into mature RNAs that act in pre-mRNA splicing, RNA modification, translation, gene silencing, and the regulation of developmental timing. The recently solved structure of an RNase III endonuclease domain provides a hint at how this family of ribonucleases functions. |
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