Ragweed allergen Ra3: Relationship to some type 1 copper-binding proteins |
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Authors: | Lois T Hunt David G George Lai-Su L Yeh |
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Institution: | (1) Georgetown University Medical Center, National Biomedical Research Foundation, 3900 Reservoir Road, NW, 20007 Washington, DC, USA |
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Abstract: | Summary We have found ragweed allergen Ra3 to be related to the type 1 copper proteins; it is most closely related to stellacyanin and basic blue protein. The type 1 copper proteins form a diverse group of proteins, most of which are involved in electron transport. However, key amino acids believed to be involved in copper binding are absent from the allergen sequence; thus, the allergen is not likely to be functionally related to the type 1 copper proteins. We have grouped these proteins into one superfamily and we depict the relationships among them by an evolutionary tree. As indicated by this tree, an ancient gene duplication resulted in the divergence of plastocyanin from the line leading to basic blue protein, stellacyanin, and allergen Ra3.This paper is dedicated to the memory of Professor Margaret O. Dayhoff, whose contributions to the study of protein evolution made this investigation possible |
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Keywords: | Ragweed allergen Ra3 Stellacyanin Basic blue protein Plastocyanin Azurin Type 1 copper-binding proteins Distantly related protein sequences Protein superfamily Evolutionary tree Computer methods |
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