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A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors |
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| Authors: | K Tilgner I Neganova I Moreno-Gimeno J Y AL-Aama D Burks S Yung C Singhapol G Saretzki J Evans V Gorbunova A Gennery S Przyborski M Stojkovic L Armstrong P Jeggo M Lako |
| Abstract: | |
| Keywords: | non homologous end joining (NHEJ) double strand break (DSB) induced pluripotent stem cells (iPSC) human pluripotent stem cells Ligase IV deficiency ionising radiation (IR) |