Functional Cortical Hubs in the Eyes-Closed Resting Human Brain from an Electrophysiological Perspective Using Magnetoencephalography |
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| Authors: | Seung-Hyun Jin Woorim Jeong Jaeho Seol Jiyeon Kwon Chun Kee Chung |
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| Affiliation: | 1. MEG center, Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.; 2. Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.; 3. Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul, Korea.; 4. Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.; 5. Seoul National University College of Medicine, Seoul, Korea.; Beijing Normal University, Beijing, China, |
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| Abstract: | It is not clear whether specific brain areas act as hubs in the eyes-closed (EC) resting state, which is an unconstrained state free from any passive or active tasks. Here, we used electrophysiological magnetoencephalography (MEG) signals to study functional cortical hubs in 88 participants. We identified several multispectral cortical hubs. Although cortical hubs vary slightly with different applied measures and frequency bands, the most consistent hubs were observed in the medial and posterior cingulate cortex, the left dorsolateral superior frontal cortex, and the left pole of the middle temporal cortex. Hubs were characterized as connector nodes integrating EC resting state functional networks. Hubs in the gamma band were more likely to include midline structures. Our results confirm the existence of multispectral cortical cores in EC resting state functional networks based on MEG and imply the existence of optimized functional networks in the resting brain. |
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