| 鼠疫减毒活疫苗研究现状与展望 |
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| 引用本文： | 郭晓,仝泽辉,杜宗敏. 鼠疫减毒活疫苗研究现状与展望[J]. 微生物学报, 2023, 63(2): 567-581 |
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| 作者姓名： | 郭晓 仝泽辉 杜宗敏 |
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| 作者单位： | 军事科学院军事医学研究院微生物流行病研究所 病原微生物生物安全国家重点实验室, 北京 100071;安徽医科大学基础医学院, 安徽 合肥 230032 |
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| 基金项目： | 病原微生物生物安全国家重点实验室开放课题(SKLPBS2135) |
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| 摘 要： | 鼠疫(plague)是由鼠疫耶尔森氏菌(Yersinia pesits)引起的烈性传染病，在人类历史上曾造成约2亿人的死亡，在我国被列为甲类传染病。由于鼠疫菌具有高度致病性、传染性，被列为最具潜力的生物战剂和生物恐怖剂。在面临鼠疫威胁时，疫苗是最为有力的武器。鼠疫疫苗研究中，减毒活疫苗是重要的研究方向，现就鼠疫减毒活疫苗的研究现状进行综述，为新疫苗的研制提供参考。
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| 关 键 词： | 鼠疫 鼠疫耶尔森氏菌 减毒活疫苗 |
| 收稿时间： | 2022-07-01 |
Live-attenuated Yersinia pestis vaccines |
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| GUO Xiao,TONG Zehui,DU Zongmin. Live-attenuated Yersinia pestis vaccines[J]. Acta microbiologica Sinica, 2023, 63(2): 567-581 |
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| Authors: | GUO Xiao TONG Zehui DU Zongmin |
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| Affiliation: | State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China;School of Basic Medical Science, Anhui Medical University, Hefei 230032, Anhui, China |
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| Abstract: | Plague caused by Yersinia pestis is a fulminating infectious disease, resulting in nearly 200 million deaths in human history. It is listed as a category A infectious disease in China. As a highly infectious pathogen, Y. pestis is considered one of the most potential biological weapons and biothreat agents. Prophylactic vaccination is a powerful measure for counteracting this disease. In the development of plague vaccines, live-attenuated vaccine is an important research direction. This review introduces the recent progress, current challenges, as well as the future prospects on the development of live-attenuated plague vaccines. |
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| Keywords: | plague Yersinia pestis live-attenuated vaccine |
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