Re-evaluation of the pathogenic roles of nonstructural protein 1 and its antibodies during dengue virus infection |
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| Authors: | Yung-Chun Chuang Shu-Ying Wang Yee-Shin Lin Hong-Ru Chen Trai-Ming Yeh |
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| Affiliation: | 1.Center of Infectious Disease and Signaling Research, Medical College, National Cheng Kung University, Tainan, Taiwan;2.Department of Microbiology and Immunology, Medical College, National Cheng Kung University, Tainan, Taiwan;3.Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan, Taiwan;4.Department of Medical Laboratory Science and Biotechnology, Medical College, National Cheng Kung University, Tainan, Taiwan |
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| Abstract: | Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage and abnormal hemorrhage are the two major pathogenic changes found in these patients. From previous studies, it is known that both antibodies and cytokines induced in response to DENV infection are involved in the immunopathogenesis of DHF/DSS. However, the role of viral factors during DENV infection remains unclear. Nonstructural protein 1 (NS1), which is secreted in the sera of patients, is a useful diagnostic marker for acute DENV infection. Nevertheless, the roles of NS1 and its antibodies in the pathogenesis of DHF/DSS are unclear. The focus of this review is to evaluate the possible contributions of NS1 and the antibodies it induces to vascular leakage and abnormal hemorrhage during DENV infection, which may provide clues to better understanding the pathogenesis of DHF/DSS. |
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| Keywords: | Endothelium Permeability Hemorrhage Pathogenesis |
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