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Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver |
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| Authors: | Mari Hashimoto Kaoru Kobayashi Mio Watanabe Yasuhiro Kazuki Shoko Takehara Asumi Inaba Shin-ichiro Nitta Naoto Senda Mitsuo Oshimura Kan Chiba |
| Institution: | *Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan;†Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science and Tottori 683-8503, Japan;§Chromosome Engineering Research Center (CERC), Tottori University, Tottori 683-8503, Japan;**Mitsubishi Chemical Medience Corporation, Ibaraki 305-0047, Japan |
| Abstract: | |
| Keywords: | 25-hydroxy-cholesterol HMG-CoA synthase 1 squalene epoxidase sterol regulatory element-binding protein-2 cytochrome P450 3A |
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