Plasmids that mobilize bacterial chromosome

Cma can now be accepted as a common property of plasmids rather than one limited to a few, intensively studied examples. The mechanisms by which plasmids mobilize chromosome, in particular the role of plasmid integration into the bacterial chromosome and the part played by insertion sequences, are areas to which future interest should be directed. Solutions to these problems will be instructive in our understanding of plasmid and bacterial chromosome structure and function. The role of the IncP-1 plasmids can be expected to be central to this future work.The wide variety of bacterial genera for which conjugational analysis, mapping, and recombinant isolation are now available has extended microbial genetics into new areas. These advances are promising for the solution of a variety of practical problems in medicine, agriculture, and environmental science in the foreseeable future.