Zwitterionic polymersomes in an ionic liquid: room temperature TEM characterization |
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Authors: | Maddikeri Raghavendra R Colak Semra Gido Samuel P Tew Gregory N |
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Affiliation: | Department of Polymer Science and Engineering, University of Massachusetts-Amherst, Conte Research Center for Polymers, 120 Governors Drive, Amherst, Massachusetts 01003, United States. |
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Abstract: | Conventional transmission electron microscopy (TEM) was utilized to characterize vesicles formed by the spontaneous self-assembly of a novel zwitterionic block copolymer in the ionic liquid (2-hydroxyethyl)dimethylammonium methanesulfonate as well as in 0.1 M phosphate buffered saline (PBS). This block copolymer was synthesized via ring-opening metathesis polymerization (ROMP) of a norbornene-based sulfobetaine, followed by its end-functionalization with polystyrene to generate the necessary amphiphilic structure. The ionic liquid enabled the visualization of the vesicles in their swollen state by TEM, demonstrating a new method for improved characterization of polymer vesicles. |
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