Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives |
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| Authors: | Dou Dengfeng Alex Deepu Du Bingfan Tiew Kok-Chuan Aravapalli Sridhar Mandadapu Sivakoteswara Rao Calderone Richard Groutas William C |
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| Institution: | Department of Chemistry, Wichita State University, Wichita, KS 67260, USA. |
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| Abstract: | A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the heterocyclic ring, a methyl group, and a phenyl ring for optimal manifestation of antifungal activity. |
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