An azo-based PNA monomer: synthesis and spectroscopic study |
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| Authors: | Moustafa Mohamed E Hudson Robert H E |
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| Institution: | Department of Chemistry, The University of Western Ontario, London, Ontario, Canada. |
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| Abstract: | The full synthetic details and photospectroscopic characterization of a peptide nucleic acid (PNA) monomer suitable for Fmoc-based oligomerization chemistry that bears an azobenzene moiety as a base surrogate are reported. The monomer showed the ability to quench the fluorescence emission of fluorescein and pyrene luminophores and proved to be a competent F?ster resonance energy transfer partner in a PNA-based molecular beacon. |
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