Problem of boundary layers in the exchange diffusion of water across bimolecular lipid membranes |
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| Authors: | C T Everitt W R Redwood D A Haydon |
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| Affiliation: | 1. Dept. of Civil Engineering, Gyeongsang National University, Jinju, 52828, South Korea;2. Dept. of Civil Engineering, The University of Texas at Arlington, Texas, 76019, USA;1. Department of Civil and Environmental Engineering, Myongji University, 116 Myongji-ro, Cheoin-gu, Yongin-si 17058, the Republic of Korea;2. Department of Architectural Engineering, Chosun University, 309, Pilmun-daero, Dong-gu, Gwangju 61452, the Republic of Korea;1. Interuniversity Research Institute for Molecular Recognition and Technological Development, Universitat Politècnica de València - Universitat de València, Camino de Vera s/n, 46022 Valencia, Spain;2. Department of Architectural Construction, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain;3. Department of Chemistry, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain;4. Department of Electronic Engineering, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain;1. Department of Architecture and Civil Engineering, Chonnam National University, Gwangju 61186, Republic of Korea;2. Biohousing Research Center, Chonnam National University, Gwangju 61186, Republic of Korea;3. School of Architecture, Chonnam National University, Gwangju 61186, Republic of Korea |
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| Abstract: | The correct value of the permeability of artificial lipid bilayers to water, as given by the diffusion of tritiated water, is in general difficult to obtain owing to the presence of relatively thick boundary layers. It is shown that forced convection usually ruptures the membrane before the boundary layers become insignificant. Three other approaches to the problem are described: the thickness of the equivalent stagnant layers has been estimated explicitly by the use of glass and cellophane membranes of known permeability, and the resulting data have been used to correct the apparent permeability of the lipid membrane, the possibility of determining the true permeability from the measurement of the apparent permeability and the time lag of the transient state has been examined and shown to be impracticable in the present systems, and the true lipid membrane permeability has been calculated from the diffusion of tritiated water in known linear velocity fields in the aqueous phases. The first and third methods give permeability coefficients in agreement with each other which are, within experimental error, equal to the osmotic permeability coefficient. |
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