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Lysosomal hydrolase activity in chorionic villi and embryonic cells in culture |
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| Authors: | Livia Poenaru Laetitia Castelnau Agnès Choiset Y. Rouquet F. Thepot |
| Affiliation: | (1) Laboratoire de génétique et de diagnostic prénatal des enzymopathies lysosomales, INSERM, U. 129, Chu Cochin, 24 rue de Fg St Jacques, 75674 Paris Cedex 14, France;(2) Laboratoire de cytogénétique, Service central d'anatomie pathologique, Hôpital St Vincent de Paul, 74 avenue Denfert-Rochereau, 75674 Paris Cedex 14, France;(3) Service de gynécologie obstétrique, Hôpital St Vincent de Paul, 74 avenue Denfert-Rochereau, 75674 Paris Cedex 14, France |
| Abstract: | Summary Fourteen lysosomal enzymes were compared in 20 cultured cell lines from chorionic biopsy and corresponding embryonic tissue after voluntary abortions. Enzymatic expression appears to be similar in cultured cells from both sources with some slightly higher levels for chorionic villi. We stress the importance of culturing chorionic villi especially in the case of enzymes ( -L-iduronidase) or diseases (I cell disease) whose expression is unusual in fresh trophoblast tissue. |
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