Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus |
| |
Authors: | Paloma Liras Juan P Gomez-Escribano Irene Santamarta |
| |
Institution: | Instituto de Biotecnología de León, INBIOTEC, Parque Científico de León, Av. Real, 1, 24006 León, Spain. paloma.liras@unileon.es |
| |
Abstract: | Streptomyces clavuligerus produces a large array of natural compounds with antibiotic, antitumor, beta-lactamase inhibition or inmunomodulating activities. The production of cephamycin C, clavulanic acid and other compounds with a clavam structure has been studied for many years. A network of regulatory mechanisms is present in S. clavuligerus to control the formation of different compounds by pathway-specific regulators or pleiotropic regulators. The possible existence of a gamma-butyrolactone signaling system in this streptomycete is emerging. In addition, S. clavuligerus possesses a stringent control mechanism somehow different from those previously reported in other Streptomyces species. |
| |
Keywords: | Clavulanic acid Cephamycin C Regulation Streptomyces clavuligerus ppGpp Pleiotropic regulatory factors γ -butyrolactone |
本文献已被 PubMed SpringerLink 等数据库收录! |
|