Synthesis and activity against HBV of novel Tetra-seconucleoside analogues of dyphlline having the acyclic chains of ACV and HBG |
| |
Authors: | El Ashry El Sayed H Awad Laila F Rashed Nagwa Abdelrahman Adel Rasheed Hana A |
| |
Affiliation: | Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt. Eelsahry60@hotmail.com |
| |
Abstract: | Selective alkylation of dyphylline (1) with (2-acetoxyethoxy)methyl bromide (2a) or 4-acetoxybutyl bromide (2b) afforded 3'-O-[(acetoxyethoxy)methyl]dyphylline (3a) and 3'-O-(4-acetoxybutyl)-dyphylline (3b), respectively. A trans esterification process rather than alkylation of the dihydroxy-propyl side chain in 1 had taken place during the reaction with 2-p-toluoyloxy)ethyl chloride (5) to afford the respective 3'-toluoyloxy derivative 7 and not the anticipated 3'-O-[(p-toluoyloxy)ethyl]-dyphylline (6). Deacylation of 3a,b and 7 afforded 4a,b and 1, respectively. Viral screening of selected compounds against HBV has been investigated. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|