Prostaglandin-induced enhancement of the in vitro anamenstic response |
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Authors: | Herbert B Herscowitz William A Stylos |
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Institution: | Department of Microbiology, Georgetown University Schools of Medicine and Dentistry, Washington, D.C. 20007, USA;Worcester Foundation for Experimental Biology Shrewsbury, Massachusetts 01545, USA |
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Abstract: | The ability of various prostaglandins (PGs) to affect the in vitro anamnestic immune response of keyhole limpet hemocyanin (KLH)-primed rabbit popliteal lymph node cells was investigated. Of the four PGs studied (PGA1, PGE2 and PGF2α), PGE1 was found to have a stimulatory effect, whereas PGA1, PGE2 and PGF2α were ineffective in stimulating or inhibiting the in vitro anamnestic response. Under the conditions studied, a 3.5-fold increase in antibody production was obtained in PGE1-treated, KLH-stimulated cultures. Maximum enhancement was obtained when 0.2 μg of PGE1 were added at the time of culture initiation and were allowed to remain in contact with the lymph node cells for 24 hours. |
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