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| 细胞色素c蛋白序列分析与结构比较 | |
| 引用本文： | 王中华,王伟,李洋,林英武,黄仲贤. 细胞色素c蛋白序列分析与结构比较[J]. 生物信息学, 2010, 8(3): 274-278 |
| 作者姓名： | 王中华 王伟 李洋 林英武 黄仲贤 |
| 作者单位： | 1. 西华师范大学化学化工学院,四川,南充,637002 2. 南华大学化学化工学院,湖南,衡阳,421001 3. 复旦大学化学系,上海,200433 |
| 基金项目： | 西华师范大学科研基金 |
| 摘 要： | 首先以马心细胞色素c(Horse Cytc)蛋白的氨基酸序列为查询序列,利用生物信息学方法进行相似性搜索,获得了一系列细胞色素c(Cytc)蛋白的氨基酸序列,然后对Cytc蛋白进行了多重对齐分析、进化分析和三维结构比较分析。分析结果表明:Cytc中某些特定部位的氨基酸残基高度保守;相近物种来源的Cytc具有较近的亲缘关系,而来源于同一物种不同部位的Cytc却具有较远的亲缘关系;来源于不同物种的Cytc,即使具有较远的亲缘关系,却具有极其相似的三维空间结构。这些研究结果将为基于Cytc进行蛋白分子设计与构建提供指导意义。 |
| 关 键 词： | 细胞色素c 蛋白序列分析 分子设计 生物信息学 |
Sequence analysis and structure comparison of cytochrome c proteins |
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| WANG Zhong-hua,WANG Wei,LI Yang,LIN Ying-wu,HUANG Zhong-xian. Sequence analysis and structure comparison of cytochrome c proteins[J]. Chinese Journal of Bioinformatics, 2010, 8(3): 274-278 | |
| Authors: | WANG Zhong-hua WANG Wei LI Yang LIN Ying-wu HUANG Zhong-xian |
| Affiliation: | 1.College of Chemistry and Chemical Engineering,China West Normal University,Nanchong 637002,China;2.College of Chemistry and Chemical Engineering,University of South China,Hengyang 421001,China;3.Department of Chemistry,Fudan University,Shanghai 200433,China) |
| Abstract: | A series of cytochrome c（Cyt c） proteins were retrieved by means of bioinformatics methods based on the amino acid sequence of horse heart cytochorme c.Then the obtained protein sequences of Cyt c were analyzed by alignment,evolution and 3D structure comparison.Analytical Results show that some amino acids are highly conservative in cytochromes c（Cyts c）;Cyts c of the same tissues from similar species have related genetic relationship,but Cyts c of different tissues from the same species have remote relationship;Cyts c from various species,even though they have ulterior sibship,have very similar tertiary structures.These results would shed light on the study of protein design construction based on Cyt c. |
| Keywords: | Cytochrome c Protein sequence analysis Molecular design Bioinformatics |
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