The role of Notch and Rho GTPase signaling in the control of dendritic development |
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Authors: | Redmond L Ghosh A |
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Affiliation: | Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore MD 21205, USA. lredmond@jhmi.edu |
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Abstract: | Dendritic patterning exerts a profound influence on neuronal connectivity. Recent studies indicate that mammalian Notch receptors are expressed by postmitotic neurons and that Notch signaling has a considerable influence on dendritic growth and branching. Investigations into the intracellular effectors of dendritic development have revealed that dendritic growth and branching are differentially affected by activation of the Rho-family GTPases, RhoA, Rac1, and Cdc42. These observations suggest that the differential activation of Notch receptors and Rho-family GTPases by extracellular signals may be important in the generation of morphological diversity in the developing nervous system. |
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