Oscillatory models of the hippocampus: A study of spatio-temporal patterns of neural activity |
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Authors: | Roman Borisyuk Frank Hoppensteadt |
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Institution: | (1) Centre for Neural and Adaptive Systems, School of Computing, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UK, GB;(2) Institute for Mathematical Problems in Biology, Russian Academy of Sciences, Pushchiko, Moscow Region, 142 292, Russia, RU;(3) Center for Systems Science, Arizona State University, Tempe, AZ 85287-7606, USA, US |
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Abstract: | Spatial patterns of theta-rhythm activity in oscillatory models of the hippocampus are studied here using canonical models
for both Hodgkin's class-1 and class-2 excitable neuronal systems. Dynamics of these models are studied in both the frequency
domain, to determine phase-locking patterns, and in the time domain, to determine the amplitude responses resulting from phase-locking
patterns. Computer simulations presented here demonstrate that phase deviations (timings) between inputs from the medial septum
and the entorhinal cortex can create spatial patterns of theta-rhythm phase-locking. In this way, we show that the timing
of inputs (not only their frequencies alone) can encode specific patterns of theta-rhythm activity. This study suggests new
experiments to determine temporal and spatial synchronization.
Received: 31 July 1998 /Accepted in revised form: 20 April 1999 |
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Keywords: | |
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