Effect of synthetic enantiomeric cannabinoids on platelet aggregation. |
| |
| Authors: | I Nathan G Agam R Mechoulam A Dvilansky A A Livne |
| |
| Institution: | Department of Clinical Biochemistry, Ben Gurion University of the Negev, Beer-Sheva, Israel. |
| |
| Abstract: | The effect of a synthetic pair of enantiomeric cannabinoids on platelet function was evaluated. The nonpsychotropic enantiomer, the 1,1-dimethylheptyl homolog of (+)-(3S,4S)-7-hydroxy-delta-6-tetrahydrocannabinol (HU-211), was found to be more active in inhibiting ADP-induced platelet aggregation than the highly psychotropic (-)-enantiomer (HU-210). The related (+)-(3R,4R) cannabinoid, HU-213, which lacks the 7-hydroxy moiety, exerted its inhibitory effect within a wider range of concentrations. The results indicate a differentiation between psychotropic activity and inhibition of platelet aggregation in the cannabinoid group of compounds. |
| |
| Keywords: | |
|
|
