D-LSD binding to brain homogenates: possible relationship to serotonin receptors |
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Authors: | J L Bennett G K Aghajanian |
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Institution: | Department of Psychiatry and Pharmacology, Yale University School of Medicine, Connecticut Mental Health Center, 34 Park Street, New Haven, Connecticut 06508, USA |
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Abstract: | Using a rapid filtration technique we find stereospecific high-affinity -LSD binding (4 × 10?9M, half-saturation) in brain fractions from a number of subcortical as well as cortical brain regions. Among the putative neurotransmitters tested only serotonin effectively displaces -LSD from this specific binding site. Moreover, only the serotonin-displaceable component of binding is saturable in a high-affinity range. No change is observed in specific -LSD binding in forebrain homogenates from rats in which ascending serotonergic pathways are destroyed by lesions in the raphe nucleus. We conclude that a vast majority of the -LSD binding sites may be associated with a postsynaptic serotonin receptor rather than a presynaptic receptor associated with serotonergic (raphe) inputs. |
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