IL-10 Genetic Polymorphisms Were Associated with Valvular Calcification in Han,Uygur and Kazak Populations in Xinjiang,China |
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Authors: | Yong An Yong-Tao Wang Yi-Tong Ma Muhuyati Wulasihan Ying Huang Dilare Adi Yi-Ning Yang Xiang Ma Xiao-Mei Li Xiang Xie Ding Huang Fen Liu Bang-Dang Chen |
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Affiliation: | 1. Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 P.R. China.; 2. Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054 P.R. China.; Cincinnati Children''s Medical Center, UNITED STATES, |
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Abstract: | ObjectiveValvular calcification occurs via ongoing endothelial injury associated with inflammation. IL-10 is an anti-inflammatory cytokine and 75% of the variation in IL-10 production is genetically determined. However, the relationship between genetic polymorphisms of IL-10 and valvular calcification has not been studied. The objective of this study was to investigate the association between valvular calcification and IL-10 genetic polymorphisms in the Han, Uygur and Kazak populations in China.Patients and MethodsAll of the participants were selected from subjects participating in the Cardiovascular Risk Survey (CRS) study. The single nucleotide polymorphisms (SNPs) rs1800871 and rs1800872 of the IL-10 gene were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Three independent case-control studies involving the Han population, the Uygur population and the Kazak population were used in the analysis.ResultsFor the Han and Kazak populations, rs1800871 was found to be associated with valvular calcification in the recessive model, and the difference remained statistically significant following multivariate adjustment (p<0.001, p=0.031, respectively). For the Han, Uygur and Kazak populations, rs1800872 was found to be associated with valvular calcification in the dominant model, and the difference remained statistically significant following multivariate adjustment (p<0.001, p=0.009, and p=0.023,respectively)ConclusionBoth rs1800871 and rs1800872 of the IL-10 gene are associated with valvular calcification in the Han and Kazak populations in China. Rs1800872 is also associated with valvular calcification in the Uygur population. |
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