5'-carbamoylphosphonyl-[6-3H]-AZT as a tool for studying metabolic transformations of the nonradioactive counterpart, an inhibitor of HIV replication |
| |
| Authors: | Yanvarev Dmitry V Shirokova Elena A Astapova Maria V Shram Vyacheslav I Kukhanova Marina K Skoblov Yury S |
| |
| Institution: | Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. JDmitry@hotmail.com |
| |
| Abstract: | An effective synthesis of 5'-carbamoylphosphonyl-6-3H]-AZT was developed from 6-3H]-AZT.For the synthesized compound, chemical and enzymatic stability were determined and its penetration across HL-60 cell membranes was studied. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
