电刺激联合干细胞修复周围神经损伤的研究进展

周围神经损伤在创伤中较为常见,易造成神经系统部分或全部损伤,从而导致功能丧失和其他神经性疾病．尽管周围神经损伤的治疗效果随着科技的发展有了明显提高,但距离真正的形态和功能重建还相差甚远,神经再生及功能恢复速度缓慢仍是临床治疗的难点．电刺激因使用方便、无创和副作用小等优点越来越受到研究者的青睐,与干细胞联合广泛用于周围神经损伤修复的体外研究．本文论述了电刺激联合干细胞在周围神经损伤修复方面的研究进展,并讨论了其可能的作用机理．特别分析了电刺激联合干细胞在周围神经损伤修复研究中的难点,展望了其发展前景．

Research Advancement on Injured Peripheral Nerve Regeneration by Stem Cells Combined With Electrical Stimulation

Injury of peripheral nerve is very common in trauma, which easily causes partial or whole damage to peripheral nerves and will further result in function loss or other neurological diseases. With the development of technology, the treatment efficacy of peripheral nerve injury has been improved significantly. However, it is still very difficult to obtain the morpgologic and functional regeneration. Slow rates of nerve regeneration and functional recovery are still the difficulty in clinics. Electrical stimulation is convenient, non-invasive and with few side effects. More and more researchers have paid attention to using stem cells combined with electrical stimulation to repair injured peripheral nerve. In this study, the applications and advancement of using stem cells combined with electrical stimulation in injured peripheral nerve regeneration were comprehensively reviewed. The possible mechanisms of them were further discussed. Particularly, the difficulties of using stem cells combined with electrical stimulation to repair injured peripheral nerve were analyzed. Prospect along this direction was also discussed.