Genetic resistance to murine leukemia induced by different radiation leukemia virus variants; a comparative study on the role of theH-2 complex |
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Authors: | Peter Lonai Nechama Haran-Ghera |
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Institution: | (1) Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel |
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Abstract: | Association of resistance to leukemogenesis with theH-2 complex was investigated. Three variants of the radiation leukemia virus: D-RadLV, RadLV and RS-RadLV were tested. Using congenic and recombinant mouse strains, the region includingH-2K andI-A/B was found to be involved with resistance to all three viruses. In addition,H-2D-region linked resistance was found in leukemogenesis in two of the three passages. The phenotypic expression of resistance associated withH-2D seemed to depend on the simultaneous presence ofH-2K-H-21-linked resistance alleles. TheH-2 haplotypes associated with resistance or sensitivity to the different RadLV variants were different for each passage, suggesting that there is a large degree of heterogeneity both inH-2-linked resistance and between the radiation-induced leukemia viruses. |
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