Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin |
| |
| Authors: | Jethwa Preeti H Small Caroline J Smith Kirsty L Seth Asha Darch Sarah J Abbott Caroline R Murphy Kevin G Todd Jeannie F Ghatei Mohammad A Bloom Stephen R |
| |
| Institution: | Dept. of Metabolic Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK. |
| |
| Abstract: | Intracerebroventricular (ICV) administration of Neuromedin U (NMU), a hypothalamic neuropeptide, or leptin, an adipostat hormone released from adipose tissue, reduces food intake and increases energy expenditure. Leptin stimulates the release of NMU in vitro, and NMU expression is reduced in models of low or absent leptin. We investigated the role of NMU in mediating leptin-induced satiety. ICV administration of anti-NMU immunoglobulin G (IgG) (5 nmol) to satiated rats significantly increased food intake 4 h after injection, an effect seen for
|
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
