Neurotransmitter Modulation of Neuronal Calcium Channels |
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Authors: | Keith S Elmslie |
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Institution: | Department of Physiology, Tulane University Health Science Center, New Orleans, Louisiana 70112, USA. kelmslie@tulane.edu |
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Abstract: | There are many different calcium channels expressed in the mammalian nervous system, but N-type and P/Q-type calcium channels appear to dominate the presynaptic terminals of central and peripheral neurons. The neurotransmitter-induced modulation of these channels can result in alteration of synaptic transmission. This review highlights the mechanisms by which neurotransmitters affect the activity of N-type and P/Q-type calcium channels. The inhibition of these channels by voltage-dependent and voltage-independent mechanisms is emphasized because of the wealth of information available on the intracellular mediators and on the effect of these pathways on the single-channel gating. |
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Keywords: | N-type P/Q-type G protein betagamma subunit inhibition facilitation potentiation |
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