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Morphinan cyclic imines and pyrrolidines containing a constrained phenyl group: High affinity opioid agonists |
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| Authors: | Stephen M. Husbands John W. Lewis |
| Affiliation: | School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, England |
| Abstract: | A series of morphinan derivatives which are cyclic imines and pyrrolidines containing a constrained phenyl group has been synthesised and tested for their opioid receptor binding affinity. In opioid binding assays the ligands displayed very high affinity particularly for μ receptors and some showed substantial μ selectivity. |
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