| 甲/福流/8/58(H2N2)血凝素基因对该病毒在地鼠鼻甲中繁殖性状的影响 |
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| 引用本文： | 田淑芳,B.R.Murphy. 甲/福流/8/58(H2N2)血凝素基因对该病毒在地鼠鼻甲中繁殖性状的影响[J]. 病毒学报, 1985, 0(2) |
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| 作者姓名： | 田淑芳 B.R.Murphy |
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| 作者单位： | 中国预防医学中心病毒学研究所(田淑芳)，美国国立卫生研究院过敏性和传染性疾病研究所(B.R.Murphy) |
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| 摘 要： | 用在地鼠鼻甲繁殖不好、但在肺中繁殖较好的甲/福流/8/58(H2N2)流感病毒,与在地鼠的上下呼吸道均能较好地繁殖的H3N2型病毒重组,所获重组株(福R3),除HA基因是来自H2N2外,其它基因均来自H3N2。该重组病毒像亲本株H2N2株一样,在地鼠鼻甲繁不好。结果表明,编码甲/福流/8/58病毒的H2血凝素的基因影响着地鼠的组织嗜性。
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| 关 键 词： | 流感病毒 基因重组 繁殖性状 |
THE HEMAGGLUTININ OF INFLUENZA A/FUZHOU/ 8/58 ( H2N2 ) VIRUS AFFECTS REPLICATION IN THE NASAL TURBINATES OF HAMSTERS |
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| Tian Shufang Brian R. Murphy Institute of Virology,China National Centre for Preventive Medicine. National Institute of Allergy and Infectious Diseases,NIH,U S A.. THE HEMAGGLUTININ OF INFLUENZA A/FUZHOU/ 8/58 ( H2N2 ) VIRUS AFFECTS REPLICATION IN THE NASAL TURBINATES OF HAMSTERS[J]. Chinese journal of virology, 1985, 0(2) |
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| Authors: | Tian Shufang Brian R. Murphy Institute of Virology China National Centre for Preventive Medicine. National Institute of Allergy Infectious Diseases NIH U S A. |
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| Abstract: | The influenza A wild type virus, A/Fuzhou/8/58 ( H2N2 ) , replicated poorly in the nasal turbinates of hamsters, but replicated efficiently in their lungs.To determine which gene was responsible for this restriction of replication in the upper respiratory tract of the hamster, reassortant viruses were produced by mating the H2N2 virus with a H3N2 virus that replicates efficiently in both sites.A reassortant virus that contained all genes derived from the H3N2 virus except the hemagglutinin gene replicated poorly in the nasal turbinates like its H2N2 parent virus.This finding suggests that the H2 hemagglutinin protein of A/Fuzhou/8/58 virus is adeterminant of tissue tropism in the hamster. |
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| Keywords: | Influenza virus Genetic reassortment Replication properties. |
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