A cortical lectin from the oocytes of Rutilus rutilus stimulates mitogenic activity and release of soluble factors from human lymphocyte cultures and inhibits protein synthesis in a cell-free system |
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Authors: | F Licastro L Barbieri A Krajhanzi J Kocourek F Stripe |
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Institution: | Department of Experimental Pathology, University of Bologna, Italy. |
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Abstract: | 1. A cortical granule lectin was isolated from vitellogenic oocytes of a bony fish, the roach Rutilus rutilus. 2. The lectin agglutinates human erythrocytes, is specific for L-rhamnose and is composed of different polypeptide subunits. 3. The lectin is the first lectin of animal origin that inhibits protein-synthesis by a rabbit reticulocyte lysate, and is also mitogenic for human lymphocytes. |
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