Neuroendocrine heart and hypothalamus |
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Authors: | Armen Galoyan |
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Institution: | (1) Institute of Biochemistry, Sevag str. 5/1, 375044 Yerevan, USSR |
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Abstract: | Data on the endocrine heart—neurosecretory cells of heart, producing coronarydilatory, metabolically active glycopeptides with physico-chemical and biological properties similar to those of previously discovered cardioactive hypothalamic neurohormones—are summarized. Heart hormones participate in both local and distant regulation of heart metabolism and function. Formation and action of these heart hormones is closely related to hypothalamic cardioactive neurohormones K, C, and G and their protein precursors. Neurohormones from heart and hypothalamus comprise a system of neurohumoral connections between these two organs. A possible role of APUD cells in the generation of a number of heart peptides and glycopeptides exerting hormonal activity is discussed.Abbreviations Used NC
Neurohormone C
- NK
Neurohormone K
- NC-H
Hypothalamic NC
- NK-H
Hypothalamic NK
- PC-NC
NC cleaved from protein-carrier
- PC-NK
NK cleaved from protein-carrier
- BB-NC
Brain blood NC
- BB-NK
Brain blood NK
- H1
Substrate 1 from heart
- H2
Substrate 2 from heart
- H3
Substrate 3 from heart
- HB1
Substrate 1 from heart blood
- HB2
Substrate 2 from heart blood
- PC-H1
H1 cleaved from protein-carrier
- PC-H2
H2 cleaved from protein-carrier
- PC-H3
H3 cleaved from protein-carrier
- PC-CC
Coronaroconstrictory substance cleaved from protein-carrier
- GPG
Gomori-positive granules
- MLC
Mast-like cells |
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Keywords: | |
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