Association of apolipoprotein B gene variants with plasma apoB and low density lipoprotein (LDL) cholesterol levels |
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Authors: | Samir S Deeb R Alan Failor B Greg Brown John D Brunzell John J Albers Arno G Motulsky Ellen Wijsman |
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Institution: | (1) Department of Medicine, University of Washington, 98195 Seattle, WA, USA;(2) Department of Genetics, University of Washington, 98195 Seattle, WA, USA;(3) Center for Inherited Diseases, University of Washington, 98195 Seattle, WA, USA;(4) School of Medicine, RG-25, University of Washington, 98195 Seattle, WA, USA |
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Abstract: | Summary The contribution of the variants of the apolipoprotein (apo) B locus to the total variance in plasma apoB and cholesterol levels was examined in four independent populations, two that were composed of normal controls (n = 77 and 85) and two with coronary heart disease (n = 115 and 159). A correlation between genotype at the apoB-XbaI locus and apoB levels was observed. The effects of the (+; presence of restriction site) and (-) alleles were to increase or decrease the apoB and cholesterol levels by approximately 3.5 mg/dl, respectively. None of the 274 individuals in the coronary heart disease (CHD) groups was found to be a carrier of the apoB allele Arg3500 Gln, previously shown to be associated with an apoB protein defective in binding to the low density lipoprotein receptor (LDL-R). No DNA sequence variants were found in the region encoding amino acid residues 3129–3532 within the putative LDL-R binding domain among 35 individuals with apoB levels above the 94th percentile (141 mg/dl). |
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