Effect of thromboxane synthetase inhibitors (OKY-046, OKY-1580) on experimentally induced air embolism in anesthetized dogs |
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| Affiliation: | 1. Pesticide Science Laboratory, School of Agriculture, Faculty of Agriculture, Forestry and Natural Environment, Aristotle University of Thessaloniki, 54126 Thessaloniki, Greece;2. Laboratory of Agricultural Pharmacology and Ecotoxicology, Faculty of Agricultural Development, Democritus University of Thrace, 68200 Orestias, Greece |
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| Abstract: | We investigated the effects of OKY-046 and OKY-1580, thromboxane A2(TxA2) synthetase inhibitors, on plasma levels of 6-keto PGF2α and TxB2 in anesthetized dogs with experimentally induced air embolism.The percentage increase of tracheal pressure induced by room air infusion was suppressed significantly by premedication with OKY-046. The percentage increase of pulmonary artery blood pressure was suppressed significantly by premedication with OKY-046 compared to that in control group. By room air infusion after the premedication with OKY-046 and OKY-1580, systemic artery blood pressure did not show any significant changes. Plasma 6-keto PGF2α level showed a marked increase by an intravenous infusion of room air, and such an increase became more predominant by the premedication with OKY-046 and OKY-1580. On the other hand,plasma TxB2 level showed a marked increase by an intravenous infusion of room air, and such an increase became less predominant by the premedication with OKY-046 and OKY-1580. These results may suggest that OKY-046 and OKY-1580 are not only TxA2 synthetase inhibitors but also PGI2 synthetase accelerators and are useful drugs for treatment and prevention of thromboembolism. |
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