Acute effects of ammonia on the enzymes of citric acid cycle in rat brain |
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| Institution: | 1. Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Italy; Umberto I Hospital, Rome, Italy;2. Department of Movement, Human, and Health Sciences, Division of Health Sciences, University of Rome “Foro Italico,” Rome, Italy;3. Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy;4. Department of Radiologic, Oncologic and Anatomic-Pathology Sciences, Sapienza University of Rome, Rome, Italy;5. Department of Anatomical, Histological, Forensic Medicine, and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy;6. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy |
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| Abstract: | Activities of the enzymes of citric acid cycle were determined along with aspartate and alanine aminotransferases and NADP+-isocitrate dehydrogenase in the brains of rats treated with an acute dose of ammonium acetate and compared with those of normal animals. Elevation in the activities of pyruvate, α-ketoglutarate and succinate dehydrogenases and citrate synthase was observed in hyperammonemic animals. The activities of malate, NADP+-isocitrate dehydrogenases and aminotransferases decreased under these conditions. The results suggest that ammonia toxicity might not be due to the depletion of α-ketoglutarate from citric acid cycle. |
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